Description

Stronger Neo-Minophageh is a injectable vitamin preparation from Stronger, listed for registered Australian clinics in our Vitamins range. Pack: see product images for pack format. Priced in AUD (A$210.00). Sydney dispatch, nationwide. Not a public treatment clinic.

About Stronger Neo-Minophageh

Stronger Neo-Minophageh (Stronger Neo-Minophagen, SNMC)

Instructions for Use

Indications

Improvement of liver function in chronic liver diseases;
Eczema, dermatitis, urticaria, pruritus, drug overdose or toxicoderma, stomatitis, scabies (strophulus), psoriasis, alopecia, blisters.

Contraindications The product must not be used in the following patients:

Patients with a history of hypersensitivity to any component of the product.
Patients with aldosteronism, myopathy, and hypokalemia (due to hypoxia, hypertension, etc.).
Patients with hypertension or heart disease.

Dosage and Administration For chronic liver diseases: For intravenous injection and drip infusion the usual dose is 40 mL SNMC. For drip infusion, add normal saline or glucose solution to make 250 mL. The daily dose varies according to the patient’s age and symptoms, from 40 mL up to 100 mL. For skin diseases: The usual daily dose of SNMC is 20 mL given by intravenous injection.

Adverse Reactions In a double‑blind study of the product’s use in liver disease (to expand indications, verify dosing and record safety), adverse reactions were observed in 27 of 4,451 cases (0.61%). Major adverse reactions included decreased serum potassium in 13 cases (0.29%), increased blood pressure in 5 cases (0.11%), and upper abdominal pain in 3 cases (0.07%).

Serious Adverse Reactions

Shock, anaphylactic shock (frequency unknown): Because of the risk of shock and anaphylactic shock (hypotension, syncope, dyspnea, cardiopulmonary shock, erythema, facial swelling, etc.), patients should be carefully monitored. If any abnormality appears, discontinue the product and take appropriate measures.
Anaphylactic reactions (frequency unknown): Because of the risk of anaphylactic reactions (dyspnea, facial swelling, etc.), patients should be carefully monitored. If any abnormality appears, discontinue the product and take appropriate measures.
Pseudo‑aldosteronism (frequency unknown): Rapid hypokalemia, hypokalemia, elevated blood pressure, sodium and fluid retention, edema, weight gain, etc. Because of the risk of these symptoms, patients should be carefully monitored (including measurement of serum potassium). If any abnormality appears, discontinue the product.
Hypokalemia may cause atonic weakness and muscle weakness.

Pharmacological Properties Anti‑inflammatory / Anti‑allergic actions

Antiallergic effects.
Inhibition of Arthus reaction and Schwartzman reaction.
Enhancement of inhibitory activity toward stress reactions; antagonism of anti‑granulation action; therapy of thymic atrophy‑related conditions.
Inhibition along the arachidonic acid cascade; suppression of intracellular factor phosphorylation such as PLA2, lipoxygenase, lipocortin‑1.
Stabilization of cell membranes (cytoprotective action).
Effects on leukocyte infiltration and modulation of the immune response.
Control of T‑cell activation.
Stimulatory effect on interferon; effects on NK (natural killer) cells.
Supportive effects on T lymphocytes.
Increased production of cytokines (IL‑2, IL‑10, IL‑12).
Enhancement of endogenous glucocorticoid activity.
Promotion of hepatocyte growth.
Antioxidant effects.

Special Precautions Use with caution.

Dosage Form Stronger Neo‑Minophagen (SNMC) is an injectable preparation of glycyrrhizin, the saponin component extracted from the roots (dried roots and rhizomes) of licorice that grows in the northwest region of China. Chemically, glycyrrhizin is a compound of glycyrrhetic (glycyrrhetinic) acid and two molecules of glucuronic acid.

Composition Per 20 mL:

Monoammonium glycyrrhizinate (GL) 53 mg (equivalent to glycyrrhizin 40 mg)
Glycine (JP) 400 mg
L‑Cysteine hydrochloride 20 mg